Laura Codari Deak

Laura Codari Deak

Company: Roche Innovation Center

Job title: Team & Research Project Leader, Principal Scientist


A Novel Bispecific Checkpoint Inhibitor Antibody to Preferentially Block PD-1 & LAG-3 on TILs Whilst Sparing Treg Activation 9:30 am

Improved targeting to tumor-reactive T-cells rather than Tregs due to the selectivity gain and different expression patterns of PD-1 and LAG-3 on these two T-cell types Reduced internalization Fc silent-mediated resistance to drug-shaving by macrophages Increased in vitro T-cell effector functions even in the presence of Tregs, and Superiror in vivo tumor control/eradication in several…Read more

day: Day One

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